By Swansea University
Nanoparticles derived from tea leaves inhibit the growth of lung cancer cells, destroying up to 80% of them, new research by a joint Swansea University and Indian team has shown.
The team made the discovery while they were testing out a new method of producing a type of nanoparticle called quantum dots. These are tiny particles which measure less than 10 nanometres. A human hair is 40,000 nanometres thick.
Although nanoparticles are already used in healthcare, quantum dots have only recently attracted researchers’ attention. Already they are showing promise for use in different applications, from computers and solar cells to tumour imaging and treating cancer.
Quantum dots can be made chemically, but this is complicated and expensive and has toxic side effects. The Swansea-led research team were therefore exploring a non-toxic plant-based alternative method of producing the dots, using tea leaf extract.
Tea leaves contain a wide variety of compounds, including polyphenols, amino acids, vitamins and antioxidants. The researchers mixed tea leaf extract with cadmium sulphate (CdSO4) and sodium sulphide (Na2S) and allowed the solution to incubate, a process which causes quantum dots to form. They then applied the dots to lung cancer cells.
• Tea leaves are a simpler, cheaper and less toxic method of producing quantum dots, compared with using chemicals, confirming the results of other research in the field.
• Quantum dots produced from tea leaves inhibit the growth of lung cancer cells. They penetrated into the nanopores of the cancer cells and destroyed up to 80% of them. This was a brand new finding, and came as a surprise to the team.
The research, published in Applied Nano Materials, is a collaborative venture between Swansea University experts and colleagues from two Indian universities.